Oxidant and antioxidant status in children with juvenile idiopathic athritis
نویسندگان
چکیده
Results Mean age of patients was 9.6 years. Female: male ratio was 1.5 (F/M=27/18). Oligoarticular JIA was diagnosed in 21 patients, whereas polyarticular JIA and systemic JIA in 17 and in seven patients, respectively. During study period, 23 patients had active disease, while 22 patients were in remission. Mean duration of disease was 2.2 years. Serum ESR, CRP, TOC, TAC and, MPO levels were found higher in the patients with active disease than those in remission (p<0.05). No difference was found in neopterin, AOPP and thiol levels. Conclusion The results of the present study indicate that oxidantantioxidant systems are active in JIA patients during active phase. This activation in favor of oxidants is interesting. More comprehensive studies are needed to determine whether this is cause or result.
منابع مشابه
Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis.
Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease. Thirty-five children with JIA were studied, of whom 26 had active disease and 14 were receiving anti-TNF therapy (5 with Infliximab, 9 with Etanercept). Sixteen healthy controls also were studied. Saliva samples were obtained for analysis of anti...
متن کاملClinical and Serological Findings in Juvenile Patients with Idiopathic Arthritis in Southwestern of Iran
Introduction: The purpose of this study was to describe clinical features and serological findings of children with idiopathic arthritis in south-western Iran.Methods: This descriptive study included 60 patients with juvenile idiopathic arthritis who were referred to a pediatric rheumatology clinic at a university hospital during 6-month period. Initial manifestations, first laboratory tests an...
متن کاملMacrophage Activation Syndrome as the First Presentation of Juvenile Idiopathic Arthritis
Macrophage activation syndrome (MAS) is a rare feature of rheumatic disorders in children and adolescence and its presentation as the first symptom of rheumatic disorders is very infrequent. A 9-year-old girl, in whom MAS developed, was admitted to our Hospital in Tehran, Iran. She suffered from high grade fever and rash followed by multiple joint swelling months afterwards. Bone marrow aspira...
متن کاملSensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis
Background :Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with th...
متن کاملAssessment of Health Related Quality of Life (HRQL) in Egyptian Children with Rheumatic Diseases; Its Relation to Disease Activity and Functional Disability
Background Many pediatric rheumatic diseases persist into adulthood, with negative squeal from the disease or its treatment. We aimed to assess health related quality of life in a group of children with rheumatic diseases and its relation to disease activity and functional disability. Materials and Methods Fifty one patients were divided into three groups: Group 1 includes 27 patients diagnose...
متن کامل